Vaidyakalanidhi V I Varghese Vaidyan was born in the year 1907 in the small village of Panayam, His father Kayalvarathu Sri Kochidichandi Assan was a famous practitioner and teacher of nattu chikitsa. He was a kind hearted soul who looked after the sick and needy. Varghese Vaidyan was immensely inspired by the dedication of his father and decided upon a career in medicine. He also showed a keen interest to master sanskrit language. At the age of 17 he was absorbed into the Ayurvedic College, Trivanduram and stepped out of it at the age of 21 with the title of 'Vaidyakalanidhi' and also complemented it with a first rank and gold medal.

After passing out he spent a few years in the companionship of ayurvedic maestros putting into practice what he learned and later in 1929 set up his own 'Vaidyasala' in Perinad.